Which of the following cannot be changed on a CII prescription?

The ability to change certain elements on a prescription for a controlled substance, particularly a Schedule II prescription, is highly regulated due to the potential for misuse and abuse. The drug name, especially when it refers to the specific brand name of a medication, cannot be altered on a CII prescription. This is because changing the drug name could lead to confusion about which specific medication is being prescribed and may impact patient safety. This regulation ensures that the original intent of the prescriber is upheld, particularly regarding the specific efficacy and safety profile associated with that drug.

In contrast, other elements such as the drug quantity, date of issue, or patient's address may have more flexibility under certain circumstances, although they still require careful consideration and adherence to applicable regulations.